This update was focused on redesigning the core business cycle of designing, researching, and selling mind and body altering drugs. Each serum you design now has a collection of aspects which determine it's price, what contracts it will satisfy, and how much attention it will draw to your business from the authorities!
There are two major changes to the business system of LR2: the addition of aspect points, and the addition of contracts. Aspect points are an abstracted description of why certain serum traits may be wanted and come in four varieties: Mental, Physical, Sexual, and Medical. Each aspect has a value on the open market, and the more you sell the less valuable it becomes. Your marketing employees can be put to work counteracting these effects, keeping the price relatively stable long term. The value of each serum is now determined by the sum of all of it's aspects. Contracts are special orders for serum designs with a specific combination of aspects. In exchange for these strict requirements contracts offer far more money than you would earn by selling your serum on the open market. Creating new designs to meet the demands of your clients is the best way to catapult yourself to wealth and influence.
Selling serum now generates attention for your business. Attention bleeds away slowly over time, but if it reaches it's maximum value the city will be forced to take action. This includes a visit from one of their representatives, who can levy one of a number of different punishments. These punishments include a monetary fine, seizing your current inventory of serum, or destroying some of your research. New business policies have been added to help you manage your Attention. Future updates will include ways to corrupt the city representative and, eventually, or the city council she represents
There are a ton of little changes and additions throughout the game as well. Any page that references serum traits or designs has been updated to display their aspects in a convenient way. The serum design and research screens can now have serum traits sorted by research tier, alphabetically, and their aspect values. A new event for your companies head researcher has been added to help ensure you can generate the Clarity you need for your early game research. And, lastly, a bunch of bugs that were stopping progress on some side quests have been quashed.
Here's a changelog with some specifics (v0.46.1 to v0.47.1):
Spoiler (click to show/hide):