The Commonwealth, a new adventure for you as she looks at it from a distance. You had heard rumors of work here, jobs that involve something about some sort of secret society known as the Institute also known as the boogeyman of the Commonwealth. From what she was able to learn the Institute consists of scientist descendants from the Great War that went into hiding. However in recent times they plague the Commonwealth with all sorts of experiments, yet no one has seen a member of the Institute, only their synthetic humans and machines that do the work for them. No one knowns where they are located or how they are able to move about unseen, hence their nickname.
An interesting rumor you heard about their experiments is that a lot seem to be... sexual in some way. The creatures apparently are more interested in mating with human women instead of killing or eating them and that some settlements were changed in a strange way that caused them to be more attractive and extremely horny. You even heard a rumor that they transform some people into animal people or create their synthetic humans to be like that. Unfortunately you had no way to confirm it but you knew one thing; there is pay for putting a stop to the Institute's actions.
Before you left for the Commonwealth you were told of a couple factions and cities in the area to maybe check in with. There were the Minutemen, groups of settlers united to protect the Commonwealth from threats like raiders, hostile wildlife, and the Institute. There is also the people of Diamond City, a fortified city from what you were told that is in the heart of Boston. Probably your best place to go for shelter and food. There is rumors about an underground faction called the Railroad; rumor is that run away synths seek them out to hide from the Institute meaning that the Railroad is a possible alley against the Institute. There was also a report of a faction from the Brotherhood of Steel to be stationed there, but you tend to avoid them after one patrol demanded your high tech suit since these guys tend to horde technology.
From where you entered you could see the ruins of Boston in the distance to the south, not too far away but it'll take hours still. Along the way you spot small towns and neighborhoods, maybe good spots to check for possible friendly people or supplies... or maybe feral ghouls and other hostile things. You see a ruined highway also heading towards Boston, maybe a different path but it went a bit out of the way. The choice is yours to take, including a possible third option not towards the city.